Anti-atherosclerosis action of the traditional Korean medicine Bok Ryung Ban Ha -Tang in ApoE KO mice

Atherosclerosis is characterized by vascular obstruction from the deposits of plaque, resulting in reduced bloo flow. Here, we investigate that dynamic changes of bodyweight, liver weight, lipid levels, atherosclerotic lesion and liver steatosis, during the progression of atherosclerosis in ApoE KO mice. Male ApoE KO mice were fed a high fat diet (western type diet, WD) for 16 weeks. BRBHT; Bok Ryung Ban Ha -Tang, treatment of WD-fed atherosclerosis mice significantly reduced body weight, liver weight, blood pressure and lipid levels relative to the WD-fed mice. Lipid levels of T-chole, LDL, TG, Glucose were significantly decreased in the BRBHT treat mice compared with the WD-fed mice, also AST, ALT were significantly chaged in the BRBHT mice compared with the levels in the WD mice. Histological examination showed that the atherosclerotic lesions were reduced in the WD with BRBHT group compared with the WD group. Furthermore, the administration of BRBHT decreased fat accumulation in hepatic. Taken together, the present data indicate that BRBHT prevents atherosclerosis in WD-induced ApoE KO mice by regulation of lipid and liver steatosis.